6 Surprising Black Garlic Health Benefits & Side Effects

6 Surprising Black Garlic Health Benefits & Side Effects

We use garlic to season foods from entrees into french fries. For those who love garlic but always wished it just was not so pungent, black garlic might be the ideal solution. Black garlic doesn’t possess the same pungent odor as garlic, and it might have many different health benefits.

What is Black Garlic?

Black Garlic, a type of fermented or green garlic, has numerous health benefits that range from its powerful antioxidant nature to its possible role in cancer treatment.

Using its unique sweet taste and jelly-like consistency, it is widely known in Asia for its antioxidant properties.

Black garlic (Allium sativum L.) is a fermented product of garlic made by treating new garlic to get a mean of 10 days at high temperatures (40 to 60 °C) And higher humidity. It undergoes a Maillard reaction, which causes different compounds to form through the reaction. The response also darkens white garlic into a black color.

Pharmactive enters APAC cardiovascular market with aged black garlic extract

Processes vary widely across providers, with aging treatment ranging from 4 to 40 days. 1 study found that 21 days of therapy at 70 degrees and 90% relative humidity was best for black garlic antioxidant abilities.

While it’s possible to add black garlic into your diet, dark garlic supplements are also available.

Dark garlic is generated when fresh garlic undergoes a slow Maillard reaction, chemically altering the garlic and producing the attribute inky dark color.


When Garlic undergoes therapy to turn into black garlic, allicin, the component that provides fresh garlic its infamous odor, is transformed into a variety of different chemicals.

Black garlic has various antioxidants:

  • Amadori/Heyns compounds: These are formed during the Maillard reaction. Amadori/Heyns compounds are powerful antioxidants, and in comparison to fresh garlic, black garlic has around 40 to 100 times more of those compounds.
  • 5-hydroxymethylfurfural: This is an antioxidant that also has some anti-inflammatory consequences. In comparison with white garlic, black garlic has a higher amount of this valuable component, as 5-HMF is made under very large heat.
  • Organosulfur compounds: Diallyl sulfide, diallyl disulfide, diallyl trisulfide, and diallyl tetrasulfide
  • Pyruvate: This is an integral antioxidant and anti-inflammatory of black garlic. It reduces nitric oxide and prostaglandin E2, both of which extend and intensify inflammation.
  • S-allyl cysteine
  • Tetrahydro-β-carbolines
  • N-fructosyl glutamate
  • N-fructosyl arginine
  • Allixin
  • Selenium
  • N-alpha-(1-deoxy-d-fructose-1-yl)-l-arginine
  • Other alkaloids, polyphenols, and flavonoids

Black garlic additionally comprises nitrogen oxide, which has strong antiviral and antitumor effects.

It also contains 2-linoleoyl-glycerol, an anti-inflammatory molecule. It lowers levels of prostaglandin E2 and cytokines, which can be key promoters and signs of this inflammatory response. They prolong and improve cell death, swelling, and embarrassing symptoms of an allergy, infection, or other sicknesses.

Black garlic is rich in antioxidants and anti-inflammatory compounds, including Amadori/Heyns chemicals formed during the Maillard reaction.

Mechanism of Action

Garlic Contains a higher abundance of hydrogen-sulfur donating compounds, which are extremely important for antioxidant properties to be possible. Allicin, an unstable component of garlic, is converted to organosulfur compounds, which are more stable and contain hydrogen-sulfur donating capabilities.

Hydrogen-sulfur donating chemicals are essential to antioxidant effects because they trigger the Nfr-2 variable.

Nfr-2 factors bind to antioxidant response elements, which activate the discharge of various enzymes:

  • Heme oxygenase-1
  • Superoxide dismutase
  • Catalase
  • Quinone-oxidoreductase-1
  • Glutathione S-transferase

All Of those enzymes are important because they become powerful antioxidants, transforming damaging oxygens and nitrogens into nonreactive states that could significantly harm cells within the human body.

Black garlic exerts much of its antioxidant capacity to organosulfur compounds based on allicin.

Health Benefits of Black Garlic

Black Garlic is a secure foodstuff that can be utilized in the same manner as fresh garlic, but it has not been approved by the FDA for clinical use and generally lacks strong clinical study. Speak with your health care provider before using black garlic as a supplement.

Possibly Successful For

1) Heart Health

Black garlic improved the cholesterol of patients with mildly high cholesterol levels in a variety of studies.

At a 12-week human study (placebo) involving 60 people, 30 individuals were awarded 6 grams of black garlic two times daily before meals. It increased HDL (good) cholesterol levels in comparison with the placebo group at the close of the analysis. However, there were no changes in LDL (bad cholesterol).

Black Garlic’s elevated levels of organosulfur chemicals also relax blood vessels, which contributes to reducing blood pressure. In a 12-week analysis of 79 high blood pressure sufferers, they took 2 or 4 black garlic tablets daily. Their typical blood pressure decreased by 11.8 millimeters Hg.

Eating black garlic as part of your daily diet may help preserve or improve cardiovascular health, but more individual research is required to understand the ramifications of black garlic supplements around the heart.

Insufficient Proof For

The Following purported benefits are only supported by limited, low-quality clinical studies. There’s inadequate evidence to support the use of black garlic for any of the below-listed uses. Don’t forget to speak with a doctor before using black garlic, rather than use it in place of something your doctor recommends or prescribes.

2) Infection

Black garlic diminished blood clotting effects caused by platelet aggregation in the animal and human studies.

In human research, 5-HMF, an antioxidant found in garlic that was black, stopped the activation of nuclear factor kappa B (NF-κB).

This molecule controls the release of cytokines that prolong and stimulate TNF-α triggered cells.

TNF-α triggered cells to promote the inflammatory reaction and increase blood circulation, swelling, and defensive cells into the region.

Black Garlic also reduced the number of proteins that combine cells and make blood clots. It also lowered the number of cells that cause inflammation and cell damage.

In A cell study using macrophages (immune cells), black garlic decreased the production of nitric oxide, TNF-α, and prostaglandin E2, which are all key promoters of inflammation. It accomplished this by decreasing various protein and enzyme levels, namely of NO synthase, TNF-α, and cyclooxygenase-2 protein.

In a mouse study, rodents have been awarded 120 mg/kg of black garlic experienced decreased levels of cytokines TNF-α and IL-6 from the bloodstream.

Larger and much more potent clinical trials will be asked to ascertain the function (if any) of black garlic in combating inflammation in people. All we can say for now is that ingesting black garlic as part of a proper diet won’t hurt.

Animal & Cell Research (Lacking Evidence)

No Clinical evidence supports the use of garlic for some of the conditions listed within this part. Below is a summary of the present animal and cell-based research, which should guide additional investigational efforts. However, the research listed below shouldn’t be interpreted as encouraging of any health advantage.

3) Allergies

Allergies Are related to immunoglobulin E (IgE) antibodies and mast cells that all contribute to boosting long-term inflammation. Specifically, a type I allergy response is activated by the IgE receptor that is on the outside surface of immune cells.

A Mobile study examining a two mg/mL treatment of black garlic resulted in a decrease of the inflammatory enzymes (β-hexosaminidase and TNF-α). This averted an allergic reaction.

In another cell study, 50 μg/mL of shameful garlic inhibited crucial allergy-promoting molecules (prostaglandin E2, leukotriene B4, and cyclooxygenase-2), and prevented signaling (phosphorylation of Syk, phospholipase A2, and 5-lipoxygenase) that can lead to cell attack by the immune system cells called macrophages.

Mice treated with garlic also had a decreased allergic response visible in their skin.

Based on animal and cell studies, black garlic may decrease the markers of allergies and stop allergic reactions, but no human studies have been conducted.

4) Liver Damage

Rats with triggered oxidative liver damage were treated with garlic. Black garlic treatment substantially lowered markers of liver injury (AST, ALT, ALP, and LDH levels).

Black garlic also increased the normal activity and metabolism of the liver since the garlic raised amounts of a molecule known as CYP2E1. The garlic also decreased fatty liver residue and rebalanced liver cell diameters to optimal size.

5) Fat

In a rat study, black garlic significantly decreased stomach, stomach fat, and fat cell (adipocyte) size. The rats experienced the advantages of total diminished fat. Black garlic additionally reduced triglyceride and LDL (bad) cholesterol levels and increased HDL (good) cholesterol levels.

These possible effects have not been investigated in people.

6) Brain Modes & MSG

You have probably heard of the seasoning MSG (monosodium glutamate). In rat brain tissues, MSG damaged the Purkinje cells in the brain (cerebellum and hippocampus), but its impact on humans is uncertain.

The cerebellum and the hippocampus are critical Areas of the mind, as They control muscle coordination and earn memory retention possible. In rats, black garlic extract helped reduce Purkinje cell damage caused by MSG.

Especially because MSG is controversial (with many studies finding no harmful effects whatsoever), the relevance of the black garlic analysis on rats is unclear. Human trials will probably be required.

Cancer Research

Scientists Are investigating whether any of the active compounds of black garlic have a positive impact on cancer cells. This is very early research on cells and no particular conclusion can be drawn from it about the impact of black garlic on cancer in a living animal or person. Many chemicals have “anti-cancer” effects in cells that do not pan out in a living system.

In certain cancer cells, direct exposure to black garlic Decreases JNK and p38MAPK signaling molecules, which are heavily involved in the onset of cancer. A few of these cancer cells are the A549 lung cancer cell, HepG2 liver cancer cell, and MCF-7 breast cancer cell.

Black garlic and its active chemicals are currently being investigated in:

  • Leukemia
  • Stomach cancer
  • Colon cancer
  • Endometrial cancer

There is now nowhere near enough proof to support using black garlic at the prevention or treatment of cancer, however, mobile research is ongoing.

Supplementing with Dark Garlic

Types of Supplementation

Black Garlic is taken in tablet form as nutritional supplements, or in bulb type in Asian markets. Purées or jellies will also be available to use as spreads.

Side Effects

There are no known significant side effects of black garlic, which is considered safe to use as food.

A Rare case has been reported, where black garlic has led to a case of pneumonia. It could not be determined if it had been a resistant response or a case of toxicity.

Limitations and Caveats

Few Extensive human clinical trials are conducted, so it is difficult to predict the long-term ramifications of black garlic. Many more clinical trials will be required.

Differences Between New Garlic and Black Garlic

Black garlic has increased fructose and sugar content (as a result of the Maillard reaction it undergoes under warmth), describing its sweet flavor.

In a study of immune cells from 21 volunteers, black garlic showed stronger antioxidant activity than fresh garlic.

Fresh garlic, however, had more powerful anti-inflammatory properties due to its reduced sugar content.


Black Garlic is created through the slow fermentation of fresh garlic through the Maillard reaction. This reaction lowers the pungency of garlic and produces antioxidant Amadori/Heyns compounds.

Multiple clinical studies have found a possible advantage of black garlic for heart health, reducing cholesterol and blood pressure in people. Other studies have suggested that black garlic is mildly anti-inflammatory.

Black Garlic is available as whole bulbs, spreadable purée or jelly, or in Supplement form. It is considered safe to eat as food.

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